as far as yotes go there no such thing as to much gun , last one I shot was with 50 cal muzzle loader for bang flop , 260 rem with 120 grain ballistic tips are very effective too. I own a 204 and a 223 but have not shot yotes with them yet , I don't expect anything dramatic
from them as far as exits on coyote sized animals really unless I find that bullet that works. Tracking wounded coyotes is not something I want to do and is nearly impossible at night .