House - some (most by far) are in a big old safe. Safe was 600 lbs. empty, no idea what it weighs with the guns in it. What's not in the safe (mostly handguns and a couple long guns) are out of sight. Can't see the handguns, have to know where to reach (under/in/on top of) to put your hand on it. Long guns are in the case, magazine loaded, but not in the rifle, also out of sight.
Car - handgun are on me, when I leave the car they do, too. Unless I'm going into the county courthouse, which I try to make sure I don't have to do more than once every 5 years when I renew my concealed carry permit. On a road trip I have a rifle, or two, in the trunk of the car, or behind the seat of the truck, but we don't leave the car unattended. It's only a 4 to 5 hour trip home and everything is unloaded and carried into my mom's house when we get there.