Talk of rifles reminded me of group issues I'd seen with new guys and rifles (iron sight or scopes) when they don't get a consistent cheek weld.
I just recently saw a new pistol shooter start off with his CZ 75 Compact grouping off the black to the left. We discussed moving the rear sight but had not way to do it right then. Good thing, too. After a box or so of ammo his groups had moved to the center of the target. I asked if he had changed his point of aim and he told me he had not. He was still aiming at the center, the bullets "just moved." He'd changed the way he aligned his eye to the sights. Just like the rifle shooters do sometimes.
I would imagine it would be possible for someone to do that within a group when shooting a pistol, if they weren't really aware of it or were changing their grip (a pistol will move in your grip, like a rifle does if you're not properly set up with it). It could look like "a flyer."
Shot a round, or two, the pistol moves a little in your hand, not realized it, not correct it, the next round might not hit the same close area as the first two.
Once again, if you don't know what happened, why it happened, the pistol or the ammo might be blamed.